Reduces the reabsorption of Na+ and water. This leads to an increase in the kidney’s excreted quantity of Sodium and water. They also induce renal synthesis of prostaglandins. This contributes to their renal action including the increase in renal blood ow and redistribution of renal cortical blood flow.
High-dose furosemide is a logical and effective therapy (with other measures) for severe cardiac failure and is relatively safe when administered cautiously.