The glitazones as regularly called are agonists at the nuclear Peroxisome Proliferator-Activated Receptor-y (PPARy). PPAR-y stimulates the transcription for many of the genes responsive to Insulin.

· Synergistic effect of Pioglitazone and Metformin combination leads to beer glycaemic control
· Enhanced adherence due to reduced pill burden.
· Considered for Diabetics with first-stage Chronic Kidney disease (CKD).